Milk-Bone® Advanced Oral Care Brushing Chews® SM/Med Dogs 25-49 lbs Daily Dental Dog Treats. Loved since 1908. As effective as brushing*. Good oral care helps your dog live a healthy, happy life. Produced in Topeka, Kansas, USA. Nubs & ridges designed to help clean like bristles on a toothbrush. Fights tartar build-up and bad breath. Daily Milk-Bone® Brushing Chews®. Yearly veterinary dental checkup. Dental twist bone helps clean even hard to reach back teeth and down to the gumline. VOHC, Veterinary Oral Health Council Accepted®. Helps control tartar. Fortified with 12 essential vitamins and minerals, including calcium to help support strong bones and teeth. Guaranteed analysis: Crude protein (min.) - 12.0% Crude fat (min.) - 1.0%. Crude fiber (max.) - 8.0% Moisture (max.) - 18.0%. Calcium (min.) - 1.0%. Calorie content (calculated): Metabolizable energy (ME) 2580 kcal/kg; 63 kcal/piece. *When fed daily, Milk-Bone® Brushing Chews® are as effective as brushing a dog's teeth twice a week based on the reduction of tartar build-up. The Veterinary Oral Health Council recommends daily tooth brushing for optimal effectiveness. Milk-bone advance Oral Care®. Comments or questions Call 1-888-MILKBONE(645-5266), weekdays. Please provide product manufacturing code. www.milkbone.com. ©Big Heart Pet Brands. All rights reserved.